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June 13, 2024iScienceOpen Access

CXCL3/TGF-β-mediated crosstalk between CAFs and tumor cells augments RCC progression and sunitinib resistance

Yunxia Wang Weihong Ding Wenjing Hao Luyao Gong Yeheng Peng Jun Zhang Zhiyu Qian Ke Xu Weimin Cai Yuan Gao

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Abstract

Cancer-associated fibroblasts (CAFs) play a significant role in tumor development and treatment failure, yet the precise mechanisms underlying their contribution to renal cell carcinoma (RCC) remains underexplored. This study explored the interaction between CAFs and tumor cells, and related mechanisms. CAFs isolated from tumor tissues promoted the tumor progression and drugs resistance both

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Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e64d72b6db6435875de3d2 https://doi.org/10.1016/j.isci.2024.110224

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