June 11, 2024TrialsOpen Access

Registry-based randomised controlled trials: conduct, advantages and challenges—a systematic review

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Authors

FSFrances ShielyUniversity College Cork NSNiamh O SheaUniversity College Cork EMEllen K. MurphyUniversity College Cork

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Implication

Systematic review reveals efficiency and recruitment gains alongside data governance challenges in registry-based trials, highlighting the need for registry capability enhancement.

Key Points

Registry-based randomised controlled trials offer superior recruitment efficiency and reduced participant burden, yet data management issues persist.
Systematic review of 24 clinical trials demonstrates that 45.8% utilised multiple patient registry databases to support study conduct and outcome assessment.
Highlights the necessity to optimize registry architecture, standardise informed consent procedures, and reinforce data quality assurance protocols.

Cite This Study

Shiely et al. (2024) studied this question.

synapsesocial.com/papers/68e6542bb6db6435875e2fef https://doi.org/10.1186/s13063-024-08209-3

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Implication

Systematic review reveals efficiency and recruitment gains alongside data governance challenges in registry-based trials, highlighting the need for registry capability enhancement.

Registry-based randomised controlled trials: conduct, advantages and challenges—a systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

Registry-based randomised controlled trials: conduct, advantages and challenges—a systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

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