Wound healing treatment is a challenging strategy in skin drug delivery due to its complexities. During wound healing stages, fibroblast deposit extracellular matrix components, which majority is collagen. Fibrillar collagen, particularly collagen I, is the predominant skin collagen during the healing process. Collagen analysis is a crucial process in wound healing study since it indicates impairment process of collagen production such as scar formation which is aesthetically unwanted. Therefore, recent studies developed quantitative and qualitative evaluation of collagen fiber based on histological staining. Thus, a comprehensive discussion of those studies to provide an insight for pharmacists, dermatologists, and skin researchers to designate a precise assessment in wound healing process.
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Santoso et al. (2024) studied this question.
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