New Phenylpropanoids and Disulphides Dimers from Ferula Kuhistanica

Five undescribed compounds, including three phenylpropanoid derivatives, 4′‐methoxycinnamyl isobutyrate ( 1 ), 4′‐methoxycinnamyl‐2“‐methyl butyrate ( 2 ) and (2 Z )‐3′,4′‐dimethoxycinnamyl isovalerate ( 3 ) and two disulphides dimers, kuhistanicasulphide A ( 7 ) and kuhistanicasulphide B ( 8 ) together with five known ones, including three phenylpropanoids ( 4 – 6 ) and two disulphides ( 9 – 10 ), were isolated from the roots of Ferula kuhistanica Korovin. Their structures were elucidated on the basis of spectroscopic analysis, including IR, UV, HRESIMS, NMR and quantum 13 C NMR DP4+ probability. Anti‐inflammatory and cytotoxic (Hela, A549 and HT‐29 cell lines) activities of the obtained compounds was tested, which compounds 4 and 5 demonstrated good anti‐inflammatory with IC 50 values of 25.41±2.30 μ M and 31.70±3.82 μ M, respectively.