Effect of Tissue Angiotensins on Cardiovascular System Elements (Lecture)

Relevance. The renin-angiotensin system is now one of the oldest and most studied peptide cascades. Understanding the operation of this system is an urgent task for study in medical higher education institutions. The renin-angiotensin system is an important regulatory system that supports the metabolism and functioning of many organs, including blood vessels and the myocardium. Since cardiovascular diseases are the main cause of mortality, the study of positive and negative mechanisms of regulation of the cardiovascular system is an urgent task at the present stage. The aim of the work. To consider modern ideas about the renin-angiotensin system and its role in the regulation of homeostasis. Results. The lecture discusses the classical and tissue renin-angiotensin system, the main angiotensin metabolites, the pathways of their formation and the enzymes that catalyze these transformations. The effects realized by angiotensins through various receptors are shown. The modern point of view on the levels of organization of the renin-angiotensin system in the body and the relationship between various angiotensin antagonists is considered. Conclusion. The renin-angiotensin system is one of the most complex systems of hormonal regulation, including several organs that interact to regulate many body functions. The effects of angiotensins are complex and often oppo-site. An imbalance in the regulation of angiotensin homeostasis leads to metabolic disorders of organs and tissues and manifests itself in pathologies based on inflammatory, hypertrophic and fibrotic phenomena, and is also associated with the development of chronic diseases affecting various organs and tissues.