Key result
Local tissue renin-angiotensin systems play a crucial role in the pathogenesis of cardiovascular diseases and hypertension, acting independently of the circulating endocrine system.
This review highlights the physiological importance of local, organ-based renin-angiotensin systems in cardiovascular diseases and the value of transgenic animal models for their analysis.
No takes yet. Share an insight, caveat, or question.
Supports tissue RAS investigation in CVD research; does not yet warrant changes to clinical hypertension management.
Bäder et al. (1994) conducted a review in Cardiovascular Disease and Hypertension. Renin-Angiotensin System inhibitors was evaluated. Local tissue renin-angiotensin systems play a crucial role in the pathogenesis of cardiovascular diseases and hypertension, acting independently of the circulating endocrine system.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: