Key result
Local tissue renin-angiotensin systems play a crucial role in the pathogenesis of cardiovascular diseases and hypertension, acting independently of the circulating endocrine system.
Design
Review
Authors
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Supports tissue RAS investigation in CVD research; does not yet warrant changes to clinical hypertension management.
This review highlights the physiological importance of local, organ-based renin-angiotensin systems in cardiovascular diseases and the value of transgenic animal models for their analysis.
Bäder et al. (1994) conducted a review in Cardiovascular Disease and Hypertension. Renin-Angiotensin System inhibitors was evaluated. Local tissue renin-angiotensin systems play a crucial role in the pathogenesis of cardiovascular diseases and hypertension, acting independently of the circulating endocrine system.
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