An Analysis of Clinical, Haematological, Biochemical Profile in Dengue IgM Antibody Positive Patients at a Tertiary Care Hospital

Dengue fever is a seasonal and emerging acute mosquito-borne arboviral illness affecting tropical and subtropical countries. Prevalence of dengue infection increase in monsoon and post monsoon period. These infections may be asymptomatic or may lead to classical dengue fever (DF), or dengue hemorrhagic fever (DHF) with or without shock. Owing to lack of any diagnostic marker and any specific clinical symptoms to identify cases that will have a severe disease outcome, early diagnosis and close monitoring with symptomatic treatment is necessary. Aims and Objectives: To estimate the prevalence of dengue and to co-relate the serological, clinical, haematological and biochemical data for early diagnosis of severity of dengue infection. Materials and Methods: A cross sectional study was conducted over a period of 6 months from April 2023 to June 2023at ACS Medical College and Hospital, Chennai, a tertiary care center. Serological analysis of 30 dengue IgM antibody positive serum samples by capture ELISA method and correlation between different clinical, serological, hematological and biochemical parameters was done using SPSS software. Results: Out of 30 Dengue IgM positive patients, 26 (86.6%) were males, with mean age group of 15-25 years. 29 (96.6%) patients had fever and 13 (43.3%) had vomiting. 1 patient had co infection with malaria. Thrombocytopenia was observed in 23(76.6%) and leucopoenia in 17 (56.6%) patients. 22 (73.3%) patients had elevated transaminases. Conclusion: This study highlights the importance of clinical history, examination and investigations in timely diagnosis. This along with, helps in early treatment and reduces morbidity & mortality rate.