FADS2 confers SCD1 inhibition resistance to cancer cells by modulating the ER stress response

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Stearoyl-CoA Desaturase-1 (SCD1) inhibition as a potential therapeutic strategy for targeting lung cancer stem cells2025
2. 2Targeting Fatty Acid Desaturase I Inhibits Renal Cancer Growth Via ATF3-mediated ER Stress Response2024
3. 3Systematic analysis of fatty acid desaturases in breast invasive carcinoma: The prognosis, gene mutation, and tumor immune microenvironment2024 · 3 citations
4. 4Stearoyl-CoA desaturase 1 integrates tissue-specific oncogenic pathways into a pan-cancer ferroptosis resistance program2026
5. 5Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation2024 · 23 citations