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June 20, 2026Cell Death and DiseaseOpen Access

Stearoyl-CoA desaturase 1 integrates tissue-specific oncogenic pathways into a pan-cancer ferroptosis resistance program

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Authors

FAFrancesca AscenziIstituti di Ricovero e Cura a Carattere ScientificoGBGiovanni BlandinoNational Cancer InstituteGCGennaro CilibertoIstituti Fisioterapici Ospitalieri

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Overview

Review analyzes SCD1's role in ferroptosis resistance across malignancies, suggesting therapeutic targets.

Key Points

  • This review aims to explore how SCD1 contributes to ferroptosis resistance in various cancers and its potential as a therapeutic target.
  • Critical analysis of SCD1's function in cancer metabolism and response to therapy.
  • Examination of oncogenic pathways and microenvironmental cues affecting SCD1 activity.
  • Assessment of preclinical evidence on SCD1 targeting combined with traditional and novel therapies.
  • SCD1 activity enhances lipid desaturation, reducing susceptibility to ferroptosis across tumor types.
  • Combination therapies targeting SCD1 with ferroptosis inducers and traditional cancer treatments show promise in overcoming resistance.
  • Identification of challenges in delivering tumor-selective therapies that leverage the SCD1-ferroptosis axis.

Cite This Study

Ascenzi et al. (2026) studied this question.

synapsesocial.com/papers/6a363224db0793dc1a538d21https://doi.org/10.1038/s41419-026-08982-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Induction of stearoyl‐CoA desaturase confers cell density‐dependent ferroptosis resistance in melanoma2024 · 3 citations
  2. 2Stearoyl CoA desaturase 1 Deficiency Increases Ferroptosis Susceptibility in Chicken Embryonic Liver Cells2026
  3. 3Targeting the lipid desaturation network in cancer: from metabolic plasticity to precision therapeutics2026
  4. 4Ferroptosis Resistance: Redundant Antioxidant Networks Are a Barrier to Cancer Therapy2026 · 1 citations
  5. 5Ferroptosis in cancer: molecular mechanisms, biological roles, and therapeutic significance.2026