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This research investigates how SCD1 influences ferroptosis susceptibility and related cellular injury in chicken embryonic liver cells.

June 21, 2026Poultry ScienceOpen Access

Stearoyl CoA desaturase 1 Deficiency Increases Ferroptosis Susceptibility in Chicken Embryonic Liver Cells

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This research investigates how SCD1 influences ferroptosis susceptibility and related cellular injury in chicken embryonic liver cells.
Investigated SCD1 knockdown effects on lipid metabolism and oxidative stress in CEL cells.
Measured cellular viability, lipid droplet area, triglyceride, and cholesterol levels post-intervention.
Analyzed gene expression of ferroptosis-related factors and oxidative stress markers.
SCD1 knockdown decreased lipid droplet area and increased oxidative stress indicators (P < 0.05).
SCD1 overexpression improved mitochondrial function and antioxidant defenses, while knockdown reduced cell viability (P < 0.05).
Changes in protein levels of ACSL4, SLC7A11, GPX4, and Nrf2 were observed following SCD1 manipulation (P < 0.05).

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Randomized trial demonstrates increased ferroptosis susceptibility in chicken embryonic liver cells, suggesting SCD1's role in cellular protection.

Wei et al. (2026) studied this question.

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Randomized trial demonstrates increased ferroptosis susceptibility in chicken embryonic liver cells, suggesting SCD1's role in cellular protection.