Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance

Tommaso Scolaro; Marta Manco; Mathieu Pecqueux; Ricardo Amorim; Rosa Trotta; Heleen H. Van Acker; Matthias Van Haele; Niranjan Shirgaonkar; Stefan Naulaerts; Jan Daniluk; Fran Prenen; Chiara Varamo; Donatella Ponti; Ginevra Doglioni; Ana Margarida Ferreira Campos; Juan Fernández-García; Silvia Radenkovic; Pegah Rouhi; Aleksandar Beatovic; Liwei Wang; Yu Wang; Amalia Tzoumpa; Asier Antoranz; Ara Sargsian; Mario Di Matteo; Emanuele Berardi; Jermaine Goveia; Bart Ghesquière; Tania Roskams; Stefaan J. Soenen; Thomas Voets; Bella B. Manshian; Sarah‐Maria Fendt; Peter Carmeliet; Abhishek D. Garg; Ramanuj DasGupta; Baki Topal; Massimiliano Mazzone

doi:10.1038/s43018-024-00771-8

Abstract

Many individuals with cancer are resistant to immunotherapies. Here, we identify the gene encoding the pyrimidine salvage pathway enzyme cytidine deaminase (CDA) among the top upregulated metabolic genes in several immunotherapy-resistant tumors. We show that CDA in cancer cells contributes to the uridine diphosphate (UDP) pool. Extracellular UDP hijacks immunosuppressive tumor-associated macrophages (TAMs) through its receptor P2Y

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Scolaro et al. (2024) studied this question.

synapsesocial.com/papers/68e65d00b6db6435875eaf66 https://doi.org/10.1038/s43018-024-00771-8

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Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance

Abstract

Discussion

Cite This Study

Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance

Abstract

Discussion

Cite This Study

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