June 6, 2024MedScienOpen Access

The Inner Link between Apolipoprotein E and the risk of Alzheimer’s disease

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Narrative review reveals apolipoprotein E roles in Alzheimer's disease progression, highlighting targeted gene editing and small molecule therapies.

Variants in the APOE gene alter lipid metabolism and synaptic function, and the APOE4 allele drives elevated risk of neurodegenerative decline in Alzheimer's disease.
Mechanistic review synthesizes current evidence on apolipoprotein E pathology, noting emerging strategies like gene editing techniques and small molecule drug candidates.
Highlights the need to clarify apolipoprotein E pathways and assess the safety of gene-targeted treatments, which may enable novel clinical interventions for elderly patients.

Boyuan Zheng (2024) studied this question.

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Narrative review reveals apolipoprotein E roles in Alzheimer's disease progression, highlighting targeted gene editing and small molecule therapies.