What question did this study set out to answer?

Examine the impact of APOE on Alzheimer's disease pathogenesis and its therapeutic implications.

February 17, 2021Frontiers in NeuroscienceOpen Access

APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics

View Full Paper

Ask AI

Bookmark

Authors

Review analyzes the role of APOE in Alzheimer’s disease pathogenesis and discusses current apoE-based therapeutics.

Examine the impact of APOE on Alzheimer's disease pathogenesis and its therapeutic implications.
Reviewed existing literature on the role of APOE in Alzheimer’s disease pathogenesis and lipid transport.
Analyzed the effects of different APOE alleles on disease risk and progression.
Evaluated current apoE-based treatment strategies for Alzheimer's disease.
Carrying the ε4 allele of APOE increases the risk of developing Alzheimer’s disease.
The ε2 allele of APOE is associated with a protective effect against Alzheimer's disease.
ApoE plays a critical role in multiple CNS signaling pathways and lipid transport processes.

Husain et al. (2021) studied this question.

View Full Paper

Ask AI

Bookmark