The Effects of Sodium Fructose Diphosphate on Coagulation Factor Activity Tests in vitro

Abstract Sodium fructose diphosphate(FDP) is widely used in the treatment of patients with a variety of diseases and is highly effective. However, we have seen very few reports on the toxicity or adverse effects of this drug, and we know even less about the effects of this drug on the coagulation system. The results of our previous study showed that the drug had a significant effect on the four coagulation parameters (prothrombin time, PT; activated partial thromboplastin time, aPTT; fibrinogen, FBG; and thrombin time, TT) and platelet aggregation function. In the present study, it was found that FDP significantly prolonged the coagulation reaction time (R), a parameter routinely detected by thromboelastogram (TEG) testing systems produced by three different manufacturers, in vitro experiments. Further studies revealed that the drug had a significant inhibitory effect on the activity of coagulation factors V, VII, IX, Ⅺ, and Ⅻ, whereas it had no effect on the activity of factors II, VIII, and X. We conclude that FDP has a significant inhibitory effect on coagulation factors V, VII, IX, Ⅺ and Ⅻ activity, and thus it may really affect the function of our coagulation system.