June 5, 2024Science Translational MedicineOpen Access

High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response

View Full Paper

Ask AI

Bookmark

Authors

YMYuxin MiCentre for Human Genetics KBKatie L. BurnhamWellcome Sanger Institute PCPhilip D. CharlesNuffield Orthopaedic Centre

Discussion

Member takes

Implication

Proteomic analysis reveals distinct plasma proteome subphenotypes across 1611 critically ill patients, highlighting biomarkers and pathways for precision medicine in sepsis.

Key Points

Plasma proteome profiles distinguish clinical subphenotypes and organ failure trajectories in sepsis, reflecting dynamic host response states across acute disease stages.
High-throughput tandem mass spectrometry profiling of 2612 plasma samples was integrated with leukocyte transcriptomics to delineate dysregulated coexpression modules.
Identification of disease-specific biomarkers and conserved coexpression modules supports precision medicine approaches to target dysregulated host pathways during sepsis.

Cite This Study

Mi et al. (2024) studied this question.

synapsesocial.com/papers/68e65f84b6db6435875ed4ae https://doi.org/10.1126/scitranslmed.adh0185

View Full Paper

Ask AI

Bookmark

Implication

Proteomic analysis reveals distinct plasma proteome subphenotypes across 1611 critically ill patients, highlighting biomarkers and pathways for precision medicine in sepsis.

High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response

Discussion

Member takes

Implication

Key Points

Cite This Study

High-throughput mass spectrometry maps the sepsis plasma proteome and differences in patient response

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider