What question did this study set out to answer?

To explore the pathway-level dysregulation of the proteome in sepsis and its clinical correlates.

April 4, 2026Molecular MedicineOpen Access

Pathway-level profiling of the sepsis proteome reveals immune and transcriptional dysregulation

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Exploratory cohort study profiles 1,196 plasma proteins in sepsis, indicating complex immune responses and pathway disruptions.

To explore the pathway-level dysregulation of the proteome in sepsis and its clinical correlates.
Profiling of 1,196 plasma proteins using proximity extension assays on ICU Day 1 and Day 3.
Conducted differential expression and pathway enrichment analyses.
Performed protein-protein interaction network analyses and immune cell deconvolution.
Identified widespread inflammatory pathway dysregulation in early sepsis.
Marked enrichment of pathways related to immune activation and cytokine signaling.
Only five proteins showed temporal changes despite clinical improvement.
Negative enrichment of transcriptional pathways by Day 3 was observed.
Revealed highly interconnected inflammatory hubs centered on IL-6, IL-10, and CXCL8.

Nynatten et al. (2026) studied this question.

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