Research progress and clinical application of laser Doppler blood flow measurement technology

The laser doppler blood flow measurement technology achieves the measurement of blood flow and velocity by using laser irradiation on moving red blood cells within the human body, generating doppler frequency shifts. Compared to other blood flow measurement techniques, its output signals exhibit a strong linear relationship with blood flow, allowing for a more accurate reflection of changes in blood flow. This technology provides a convenient, user-friendly, non-invasive optical detection method for various applications, including clinical surgical assistance, blood perfusion monitoring, drug efficacy assessment, and pathological research. Ensuring the accuracy of blood perfusion measurements and the depth of tissue measurements, especially under dynamic conditions, is a key technology in the research and application of laser doppler blood flow measurement devices. This review introduces the working principles of laser doppler blood flow measurement technology, outlines the research progress of this technology and related devices in various clinical application areas, analyzes key issues influencing the accuracy of its clinical applications and the research progress of relevant technologies. It also provides prospects for the future development of this technology and its devices, offering valuable insights for the research and development of wearable microcirculation measurement devices.