Immune microenvironment and biomarker analysis of CCNE1-amplified EGC. Breakdown of immune biomarkers of CCNE1-amplified versus nonamplified EG adenocarcinoma by MMR/MSI-H status, PD-L1 (22C3) expression, and TMB high status (A). Characterization of percentage infiltration of specified immune cell populations in CCNE1-amplified versus nonamplified EGC from WTS by RNA deconvolution analysis (B). Expression of immune-related genes in CCNE1-amplified versus nonamplified from RNA sequencing (C). Immune-related gene signatures including IFNG and T cell–inflamed signatures (D). Statistical significance is displayed as the following: *, q < 0.05; **, q < 0.01; ***, q < 0.001; ****, q < 0.0001.
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Rustgi et al. (2024) studied this question.
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