Frequently occurring molecular coalterations in CCNE1-amplified EGC. Frequency of comutated genes among all CCNE1-amplified and nonamplified EG adenocarcinoma by WES and NGS (A). CNAs co-occurring with CCNE1 amplification (B). LOH with CCNE1 amplification (C). HER2 overexpression or ERBB2 amplification in CCNE1-amplified EG adenocarcinoma by CISH assays, IHC, or NGS (D). Statistical significance is displayed as the following: *, q < 0.05; **, q < 0.01; ***, q < 0.001; ****, q < 0.0001.
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Rustgi et al. (2024) studied this question.
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