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October 8, 2025BMC OphthalmologyOpen Access

Lipidomic analysis of vitreous humor derived from patients with proliferative diabetic retinopathy

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Authors

JWJiawei WangQilu Hospital of Shandong UniversityZSZheyi ShaoQilu Hospital of Shandong UniversityWLWanna LiQilu Hospital of Shandong University

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Implication

Lipid profiles show significant differences in vitreous humor of PDR patients versus controls, indicating potential biomarkers for diagnosis.

Key Points

  • PDR patients exhibited significantly higher lipid levels in vitreous humor than healthy controls, revealing distinct lipid profiles.
  • A total of 256 lipids were identified, with 245 upregulated and 11 downregulated in PDR patients based on comprehensive statistical analyses.
  • Lipidomic analysis utilized high-throughput liquid chromatography tandem mass spectrometry, enabling precise profiling of metabolic pathways.
  • Findings highlight the potential of these differentially expressed lipids as metabolic biomarkers for diagnosing and understanding PDR.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68e6679587ecc93a24d17451https://doi.org/10.1186/s12886-025-04347-7
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