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This is a Experimental Study study (also classified as: Quantitative Study).

October 8, 2025Open Access

From shallow to full wrapping: geometry and deformability dictate lipid vesicle internalization

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Experimental validation reveals how deformability affects engulfment of lipid vesicles, indicating new insights for drug delivery applications.

Deformability significantly influences the engulfment of lipid vesicles, particularly during endocytosis.
Engulfment dynamics change based on vesicle geometry, with different states observed depending on size.
3D confocal reconstructions quantify vesicle characteristics, linking experimental data with theoretical predictions.
These findings enhance understanding of vesicle uptake in various systems, including drug delivery and viral entry.

Ham et al. (2025) studied this question.

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Experimental validation reveals how deformability affects engulfment of lipid vesicles, indicating new insights for drug delivery applications.