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February 21, 2026Biophysical Journal

BPS2026 – Adhesion-dependent shape transitions of highly deflated lipid vesicles

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Authors

GWGianna C. WolfisbergJAJaime Agudo-CanalejoMax Planck Institute for Dynamics and Self-OrganizationPBP BittmannETH Zurich

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Implication

Experiment reveals how adhesion mechanisms affect vesicle morphology, implying constraints from protein-protein interactions.

Key Points

  • To investigate the influence of adhesion mechanisms on the shape of highly deflated lipid vesicles.
  • Osmotic deflation of giant lipid vesicles
  • Adhesion to supported lipid bilayers using depletion interactions
  • Quantitative shape analysis using the Canham-Helfrich model
  • Assessment of DNA-mediated vesicle adhesion and its effects on morphology
  • Achieved vesicle volumes as low as 0.1, resulting in disc-like morphologies
  • DNA-mediated adhesion did not produce flattened vesicle shapes
  • Discontinuous transition from strong adhesion to detachment observed with DNA linkers
  • Indicated that adhesion mechanisms play a critical role in determining vesicle morphology

Cite This Study

Wolfisberg et al. (2026) studied this question.

synapsesocial.com/papers/69990de85b97ab4c14ac2961https://doi.org/10.1016/j.bpj.2025.11.247
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Also Consider

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