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May 22, 2026Proceedings of the National Academy of Sciences

Dynamic bidirectional coupling of membrane morphology and rod organization in flexible vesicles

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Authors

SHStijn van der HamAMAndré F. V. MatiasMDMarjolein Dijkstra

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Overview

Randomized trial demonstrates dynamic coupling of rod organization and vesicle shape, suggesting insights into soft container assembly.

Key Points

  • To explore how the organization of rod-like particles inside flexible vesicles affects the morphology of the vesicles.
  • Combined experiments and simulations with colloidal rods in lipid vesicles.
  • Analyzed the effects of packing fractions on vesicle shape and internal organization.
  • Mapped a phase diagram identifying behaviors under different boundary conditions.
  • At lower packing fractions, elongated vesicles promote nematic alignment of rods.
  • Higher packing fractions lead to smectic-like ordering, reshaping vesicles into plate-like forms with higher bending energy.
  • Controlling vesicle volume and membrane area allows for reversible tuning of shape and internal organization.

Cite This Study

Ham et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff33bd674f7c03778bca5https://doi.org/10.1073/pnas.2604848123
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