LAYN Serves as a Prognostic Biomarker and Downregulates Tumor-Infiltrating CD8+ T Cell Function in Hepatocellular Carcinoma

Shuxiu Xiao; Lili Lu; Zhiyuan Lin; Xinming Ye; Sheng Su; Chenlu Zhang; Yang You; Wěi Li; Xiaowu Huang; Wei‐Zhong Wu; Yuhong Zhou

doi:10.2147/jhc.s464806

June 1, 2024Journal of Hepatocellular CarcinomaOpen Access

LAYN Serves as a Prognostic Biomarker and Downregulates Tumor-Infiltrating CD8+ T Cell Function in Hepatocellular Carcinoma

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Key Points

Layilin downregulates tumor-infiltrating CD8+ T cell function in hepatocellular carcinoma, acting as an indicator of immune cell exhaustion.
Elevated LAYN expression marks dysfunctional CD8+ T cells across multiple tumor types, linking immune suppression directly to tumor progression.
These observations highlight layilin as a candidate prognostic biomarker and potential therapeutic target to revitalize exhausted CD8+ T cells.

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Implication

Analysis reveals layilin downregulates CD8+ T cell function in hepatocellular carcinoma, suggesting its utility as a prognostic biomarker.

Abstract

Layilin (LAYN) represents a valuable prognostic biomarker across various tumor types, while also serving as an innovative indicator of dysfunctional or exhausted CD8

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Cite This Study

Xiao et al. (2024) studied this question.

synapsesocial.com/papers/68e669b0b6db6435875f5c30 https://doi.org/10.2147/jhc.s464806

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LAYN Serves as a Prognostic Biomarker and Downregulates Tumor-Infiltrating CD8+ T Cell Function in Hepatocellular Carcinoma

Key Points

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Implication

Abstract

Discussion

Cite This Study

LAYN Serves as a Prognostic Biomarker and Downregulates Tumor-Infiltrating CD8+ T Cell Function in Hepatocellular Carcinoma

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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