Key result
High expression of LINC01146 was an independent protective factor for overall survival in patients with hepatocellular carcinoma (HR 0.38) and inhibited tumor growth in vitro and in vivo.
Why the study?
Long non-coding RNAs are involved in the development of hepatocellular carcinoma, motivating an investigation into the function of LINC01146 in this disease.
Population
HCC tissues from TCGA, GEO, an institutional cohort, HCC cell lines, and nude mice
Comparison
LINC01146 overexpression vs downregulation vs control
Design
Preclinical in vitro and in vivo translational study with bioinformatic analysis
Authors
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LINC01146 may represent a prognostic biomarker and therapeutic target in HCC; leaves open clinical translation pending prospective trials.
Hazard Ratio: 0.38 (95% CI 0.16–0.92)
p-value: p=0.033
LINC01146 acts as a tumor suppressor in hepatocellular carcinoma, inhibiting malignant phenotypes in vitro and in vivo, and its high expression is associated with better patient prognosis.
Ma et al. (2022) studied Hepatocellular carcinoma (n=88). High LINC01146 expression vs. Low LINC01146 expression was evaluated on Overall survival (HR 0.38, 95% CI 0.16-0.92, p=0.033). High expression of LINC01146 was an independent protective factor for overall survival in patients with hepatocellular carcinoma (HR 0.38) and inhibited tumor growth in vitro and in vivo.
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