Key result
Higher LINC00882 in hepatocellular carcinoma is linked to poorer patient prognosis.
Why the study?
Hepatocellular carcinoma is often diagnosed at an advanced stage with poor therapeutic outcomes, necessitating identification of effective early diagnostic biomarkers and new therapeutic targets.
Is LINC00882 overexpression associated with poor prognosis and tumor progression in hepatocellular carcinoma?
Comparison
Upregulation of LINC00882 in HCC tissues versus normal and adjacent noncancerous tissues
Design
Observational study with in vitro cell experiments
Authors
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May inform HCC prognosis; leaves open biomarker validation and therapeutic targeting.
Observational (n=345)
Is LINC00882 overexpression associated with poor prognosis and tumor progression in hepatocellular carcinoma?
LINC00882 is upregulated in hepatocellular carcinoma, correlates with poor prognosis, and promotes tumor progression in vitro, suggesting it as a potential biomarker and therapeutic target.
Huang et al. (2018) conducted an observational in Hepatocellular carcinoma (n=345). LINC00882 overexpression vs. Normal liver tissues was evaluated on Prognosis. Upregulation of LINC00882 was significantly higher in hepatocellular carcinoma tissues compared with normal liver tissues and correlated with poorer patient prognosis.
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