Pediatric drug-induced anaphylaxis reports in the FDA Adverse Event Reporting System (FAERS)

Clinical Implications Previous research indicated that antibiotics and NSAIDs are key drug categories associated with anaphylaxis in children. However, this study suggests that monoclonal antibodies have emerged as a leading category of drugs reported to the FDA as causing "anaphylaxis" in children. It remains unclear how many of these reports are common-infusion-related reactions rather than true anaphylaxis. Previous research indicated that antibiotics and NSAIDs are key drug categories associated with anaphylaxis in children. However, this study suggests that monoclonal antibodies have emerged as a leading category of drugs reported to the FDA as causing "anaphylaxis" in children. It remains unclear how many of these reports are common-infusion-related reactions rather than true anaphylaxis.