From Inflammation to Acute Cardiovascular Events – a Complex Journey

Inflammation is a major factor in the onset and progression of atherosclerosis, which is currently considered a chronic inflammatory disease.At endothelial level, inflammation leads to increased permeability to lipoproteins and their subendothelial accumulation, inducing endothelial dysfunction.The balance between pro-and anti-inflammatory properties determines the atheroma progression. 1 The link between long-term inflammation and cardiovascular disease is well-known, and it has been demonstrated that inflammation can lead to plaque vulnerabilization, triggering an acute coronary event.Moreover, increased systemic inflammation, such as the one seen in periodontal disease or COVID-19, is correlated with atheromatous plaque progression, favoring plaque rupture or coronary thrombosis. 2 Diabetes mellitus is also