June 1, 2024Journal of Clinical Oncology

Evaluating CR as a surrogate endpoint for PFS in R/R chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): A meta-analysis of randomized controlled trials (RCT).

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Authors

LWLin WangNorth China University of Water Resources and Electric Power TDTim DisherIzaak Walton Killam Health Centre FLFei Fei LiuBristol-Myers Squibb (United States)

Discussion

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Implication

Meta-analysis of randomized controlled trials demonstrates improved complete response extends progression-free survival in relapsed chronic lymphocytic leukemia, indicating its surrogacy validity.

Key Points

Higher odds of complete response consistently reduce disease progression risk across 13 randomized trials involving 4388 patients with relapsed chronic lymphocytic leukemia.
Meta-analysis using a weighted linear model and bivariate random-effects meta-analysis evaluated trial-level surrogacy alongside cross-validation across diverse modern therapies.
Supports complete response as a valid surrogate endpoint for progression-free survival, potentially accelerating future drug approvals in relapsed small lymphocytic lymphoma.

Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e6706cb6db6435875fb2aa https://doi.org/10.1200/jco.2024.42.16_suppl.7046

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Implication

Meta-analysis of randomized controlled trials demonstrates improved complete response extends progression-free survival in relapsed chronic lymphocytic leukemia, indicating its surrogacy validity.

Evaluating CR as a surrogate endpoint for PFS in R/R chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): A meta-analysis of randomized controlled trials (RCT).

Discussion

Member takes

Implication

Key Points

Cite This Study

Evaluating CR as a surrogate endpoint for PFS in R/R chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): A meta-analysis of randomized controlled trials (RCT).

Discussion

Member takes

Implication

Key Points

Cite This Study

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