June 1, 2024Annals of the Rheumatic Diseases

Op0299 Dynamics of the B Cell Receptor Repertoire During the Preclinical Phase of Rheumatoid Arthritis: Longitudinal Studies in Untreated Ra-Risk Individuals (Domino Study) and the Effects of Rituximab Treatment (Prairi Study)

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Dominant B cell receptor heavy chain signatures disappear from plasmablasts over time and resurface as low-frequency memory B cells in individuals at risk for rheumatoid arthritis.
Adaptive immune receptor sequencing shows rituximab depletes dominant clones by 6 months, yet none returned to dominant status within 12 months.
Dynamic shifts in dominant plasma cells highlight persistent clonal turnover, which may enable targeted immune monitoring during preclinical rheumatoid arthritis progression.

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Implication

Placebo-controlled trial demonstrates rituximab alters dominant B-cell receptor clones in individuals at risk of rheumatoid arthritis, suggesting transient depletion before memory cell emergence.

Cite This Study

Musters et al. (2024) studied this question.

synapsesocial.com/papers/68e671adb6db6435875fb94e https://doi.org/10.1136/annrheumdis-2024-eular.5956

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Implication

Placebo-controlled trial demonstrates rituximab alters dominant B-cell receptor clones in individuals at risk of rheumatoid arthritis, suggesting transient depletion before memory cell emergence.

Op0299 Dynamics of the B Cell Receptor Repertoire During the Preclinical Phase of Rheumatoid Arthritis: Longitudinal Studies in Untreated Ra-Risk Individuals (Domino Study) and the Effects of Rituximab Treatment (Prairi Study)

Key Points

Discussion

Implication

Cite This Study

Op0299 Dynamics of the B Cell Receptor Repertoire During the Preclinical Phase of Rheumatoid Arthritis: Longitudinal Studies in Untreated Ra-Risk Individuals (Domino Study) and the Effects of Rituximab Treatment (Prairi Study)

Key Points

Discussion

Implication

Cite This Study

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