Synthesis and bio-evaluation of heterocyclic compound as antimicrobial agents

1, 4-Dihydropyridines (1, 4- DHPs) are Heterocyclic compounds, an important class of molecules in the field of drugs and pharmaceuticals. Dihydropyridine nucleus possess various activities like Vasodilator, bronchodilator, antiatherosclerotic, antitumor, antidiabetic and hepatoprotective agents. Interest in 1,4- dihydropyridines is due to nicotinamide adenine dinucleotide (NADH), a coenzyme, with unique ability to reduce various functional groups in biological systems. Very recently, dihydropyridines have been reported for resistance reversal properties and antitubercular activities and act as calcium channels blockers. They inhibit the movement of calcium across membrane of myocardial and smooth muscle and their block impulse formation and inhibit conduction velocity and contraction. Further recently such compounds are known to have antibacterial and antifungal activity. Present work is based on the synthesis and bio-evaluation of substituted derivative of 1, 4-Dihydropyridine.