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May 31, 2024PNAS NexusOpen Access

Trophoblast-specific overexpression of the LAT1 increases transplacental transport of essential amino acids and fetal growth in mice

Fredrick J. Rosario Kenneth Barentsen Theresa L. Powell Johann Urschitz Thomas L. Brown Yoshikatsu Kanai Thomas Jansson

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Abstract

Placental System L amino acid transporter activity is decreased in pregnancies complicated by intrauterine growth restriction (IUGR) and increased in fetal overgrowth. However, it is unknown if changes in the expression/activity of placental Large Neutral Amino Acid Transporter Small Subunit 1 (Slc7a5/LAT1) are mechanistically linked to placental function and fetal growth. We hypothesized that trophoblast-specific

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Rosario et al. (2024) studied this question.

synapsesocial.com/papers/68e67624b6db6435876006e6 https://doi.org/10.1093/pnasnexus/pgae207

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