Disease profile and main outcomes of COVID 19 in a population with nephrologic concern: a mono centric study

Abstract Background: Patients with CKD as well as patients who developed acute renal failure both affected by SARS-COV2 have a poor disease prognosis. The aim of our work: is to study the profile and outcomes of COVID 19 in patients with nephrology concern Methods: The patients included were chronic renal patients, kidney transplanted recipients and patients who developed acute renal failure. Patients were recruited over a period of one year. Results: We included 165 patients with a mean age of 57 years. There was a slight male predominance. Our patients had three main diseases (hypertension: 61.8%, diabetes: 44% and cardiovascular disease: 19%) and were obese in a third of cases. Chronic kidney disease accounted for 85% of patients. The death rate was 15.8%. The main complications were acute renal failure: 16.4%, worsened chronic renal failure 32.7%, pulmonary bacterial super infection: 23.6% and a moderate or severe form of COVID in 57% of cases. The main conclusions of the analytic study were: a significantly positive association of severe COVID 19 with advanced age (p=0.001), hypertension (63.7%, p=0.012), diabetes (66.2%, p=0.018), underlying heart disease (75%, p=0.017) and renal patients not necessitating renal replacement therapy (67.5%, p=0.044). The clinical signs most associated with moderate and severe forms of the disease (MSD) were asthenia (63.4%, p=0.024), fever (68.6%, p=00.1) and dry cough (71%, p=0.001). The main complications significantly associated with Moderate or Severe Disease were ARF (77.8%, p=0.017) and bacterial pulmonary super infection (94.9%, p<0.001). In multivariate analysis, pulmonary bacterial super infection and dry cough are clearly associated with MSD: respective OR were 37.23 and 3.434. Diarrhea appears to be a factor associated with mild forms of COVID 19 as evidenced by an OR of 0.374. Increasing age by one year multiplies the risk of developing a severe form of COVID 19 disease by 1.044. Conclusion: According to our study, the most serious COVID patients are the elderly, hypertensive, diabetic, cardiopathic patients and, above all, those who develop ARF. Some clinical symptoms and biological findings were correlated with severe disease but the strongest indicators are asthenia, dry cough and advanced age. Trial registration: not done as we did not make any health care intervention on study participants