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Review reveals mechanisms of cytotoxicity and cell death driven by extracellular ATP and ATP depletion in cellular models, highlighting pathways for targeted therapeutic strategies.
This paper delves into three pivotal themes concerning adenosine triphosphate (ATP): ATP cytotoxicity, ATP-induced cell death, and ATP depletion. Initially, we scrutinize ATP's involvement in cytotoxicity, with a specific focus on elucidating the mechanisms underlying cell demise triggered by augmented extracellular ATP concentrations. Subsequently, we investigate the process of ATP-induced cell death, emphasizing the repercussions of heightened extracellular ATP levels on cellular dynamics and associated biological responses. Lastly, we probe the impact of ATP depletion on cellular function and contemplate the plausible manifestation of cell death resulting from ATP depletion. Through a comprehensive examination of these topics, a deeper understanding of ATP's multifaceted role in cellular biology emerges, offering novel insights and strategies for the treatment and prevention of related diseases.
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Zhang et al. (2024) studied this question.
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