Glucagon infusion alters the circulating metabolome and urine amino acid excretion in dogs

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Decreased circulating amino acid levels are observed post-glucagon infusion, affecting metabolic pathways.
The high-dose glucagon infusion impacted 414 metabolites, leading to 369 reductions, with significant clustering noted.
Assessment using untargeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) on plasma and urine samples reveals key findings in metabolomics. Urine analysis showed increased 3-methyl-l-histidine and glutamine after glucagon.

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Randomized trial demonstrates glucagon's effect on plasma metabolome and urine amino acids in dogs, indicating its role in metabolism.

Merkhassine et al. (2024) studied this question.

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