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This research investigates how circulating concentrations of amino acids, glucose, and insulin contribute to glucagon secretion, especially in obesity and prediabetes.

June 10, 2026Diabetes

1327-OR: The Contribution of Circulating Amino Acid, Glucose and Insulin Concentrations to Glucagon Secretion

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This research investigates how circulating concentrations of amino acids, glucose, and insulin contribute to glucagon secretion, especially in obesity and prediabetes.
Lean (BMI: 23 ± 0.5 kg/m2, n = 10) and obese (BMI: 31 ± 0.6 kg/m2, n = 16) subjects were studied after an overnight fast.
Subjects underwent two study days with either saline or amino acid infusion to evaluate glucagon secretion rates.
Amino acids were measured by mass spectrometry at defined intervals during the study.
Insulin levels rose, while glucagon levels showed an inverse-exponential suppression during both study days.
Amino acid infusion elevated 15 specific amino acids compared to saline, impacting glucagon responses.
Arginine and histidine concentrations, adjusted for weight, correlated with a rise in G50, indicating impaired glucagon suppression in obese subjects (R2 = 0.45, p = 2.6 x 10-5).

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Implication

Randomized trial examines how amino acids, glucose, and insulin affect glucagon in lean and obese individuals, suggesting implications for diabetes risk.

Cite This Study

MOHAN et al. (2026) studied this question.

synapsesocial.com/papers/6a28ff956f82f25be989c663 https://doi.org/10.2337/db26-1327-or

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Implication

Randomized trial examines how amino acids, glucose, and insulin affect glucagon in lean and obese individuals, suggesting implications for diabetes risk.

1327-OR: The Contribution of Circulating Amino Acid, Glucose and Insulin Concentrations to Glucagon Secretion

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Discussion

Implication

Cite This Study

1327-OR: The Contribution of Circulating Amino Acid, Glucose and Insulin Concentrations to Glucagon Secretion

Key Points

Discussion

Implication

Cite This Study

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