What does this research mean for the field?

In fasted individuals with postbariatric hypoglycemia, an initial microdose of glucagon produces a predictable increase in glucose via increased endogenous glucose production, whereas subsequent doses yield diminished responses. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to quantify the glycemic response to microdoses of glucagon in individuals with postbariatric hypoglycemia (PBH).

June 7, 2026Diabetes

1368-P: Glycemic Response to Glucagon in Patients with Post-Bariatric Hypoglycemia

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This study aims to quantify the glycemic response to microdoses of glucagon in individuals with postbariatric hypoglycemia (PBH).
Enrolled individuals with PBH (0 M, 12 F, mean age 51, mean BMI 31.24 kg/m²).
Administered serial glucagon microdoses (75-450 mcg) at 30-minute intervals in randomized order.
Measured glucose turnover using [6,6-2H2] glucose infusion and collected arterialized venous blood for analysis.
Initial glucagon doses resulted in significant increases in glucose and EGP (p<0.05).
Larger initial glucagon doses led to greater glucose increases, with subsequent doses causing smaller changes.
Incremental glucose and EGP showed a strong correlation (escalation: R=0.54, p=0.02; de-escalation: R=0.68, p=0.002).

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Implication

Randomized trial quantifies the glycemic response to glucagon in individuals with postbariatric hypoglycemia, suggesting optimized dosing strategies.

Cite This Study

BROWN et al. (2026) studied this question.

synapsesocial.com/papers/6a250b2d7def13d035e1b390 https://doi.org/10.2337/db26-1368-p

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Implication

Randomized trial quantifies the glycemic response to glucagon in individuals with postbariatric hypoglycemia, suggesting optimized dosing strategies.

1368-P: Glycemic Response to Glucagon in Patients with Post-Bariatric Hypoglycemia

Key Points

Discussion

Implication

Cite This Study

1368-P: Glycemic Response to Glucagon in Patients with Post-Bariatric Hypoglycemia

Key Points

Discussion

Implication

Cite This Study