May 27, 2024Open Access

Liver Fibrosis: From Basic Science to Clinical Progress

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Authors

HAHikmet AkkızBahçeşehir University RGRobert K. GieselerUniversity Hospitals of the Ruhr-University of Bochum ACAli CanbayUniversity Hospitals of the Ruhr-University of Bochum

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Implication

Review reveals pathways driving hepatic stellate cell activation in liver fibrosis, indicating potential reversibility even at advanced cirrhosis stages.

Key Points

Hepatic stellate cells drive liver fibrosis by transdifferentiating into extracellular matrix producing myofibroblasts following chronic injury.
Single-cell technologies reveal that quiescent hepatic stellate cells are homogenous while activated myofibroblasts exhibit high heterogeneity.
State-of-the-art review characterizes the cellular drivers connecting chronic liver inflammation, macrophage activation, and tissue scarring.

Cite This Study

Akkız et al. (2024) studied this question.

synapsesocial.com/papers/68e6836bb6db64358760c19a https://doi.org/10.20944/preprints202405.1666.v1

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Implication

Review reveals pathways driving hepatic stellate cell activation in liver fibrosis, indicating potential reversibility even at advanced cirrhosis stages.

Liver Fibrosis: From Basic Science to Clinical Progress

Discussion

Member takes

Implication

Key Points

Cite This Study

Liver Fibrosis: From Basic Science to Clinical Progress

Discussion

Member takes

Implication

Key Points

Cite This Study

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