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August 16, 2026Portal hypertension & cirrhosisOpen Access

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

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Authors

MTMaryam Jadid TavafMVMahboobeh Ebrahimi VarkianiSASaeid Abroun

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Overview

Review uncovers epigenetic mechanisms driving hepatic stellate cell activation in liver fibrosis, highlighting novel therapeutic targets for experimental chronic liver disease.

Key Points

  • To summarize the core epigenetic mechanisms governing hepatic stellate cell activation and evaluate the potential of epigenetic-targeted interventions for treating liver fibrosis.
  • Synthesized molecular evidence on transcriptional and epigenetic reprogramming during the transition of hepatic stellate cells to activated myofibroblasts.
  • Assessed preclinical interventions targeting DNA methylation, histone modifications, and non-coding RNAs across experimental models of liver disease.
  • Identified DNA methylation, histone remodeling, and non-coding RNAs as pivotal drivers of excessive extracellular matrix deposition and profibrotic signaling.
  • Highlighted that while mechanism-based therapies currently lack clinical efficacy, experimental modulation of epigenetic modifications shows promise in slowing or reversing fibrosis in preclinical models.

Cite This Study

Tavaf et al. (2026) studied this question.

synapsesocial.com/papers/6a817a01f2fb91fc834ad794https://doi.org/10.1002/poh2.70064
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Also Consider

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  1. 1Mechanisms and reversal strategies of liver fibrosis: from regulation of cell fate to clinical translation2026 · 1 citations
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  4. 4Hepatocyte-hepatic stellate cell interactions in liver fibrosis: Mechanisms and therapeutic implications.2026 · 16 citations
  5. 5Review of Liver Fibrosis and Inflammation2026