In vitro study demonstrates antidiabetic and anticholinesterase activities in Thai Bao mango peel extract, indicating its potential value as a therapeutic nutraceutical byproduct.
Key Points
Bao mango peel ethanolic extract contains mangiferin as its primary phenolic compound, showing high radical scavenging ability of 4266.70 µmol TE/g extract.
In vitro enzyme assays revealed that the extract inhibited alpha-glucosidase and alpha-amylase more effectively than standard acarbose (P < 0.05).
The extract suppressed acetylcholinesterase and beta-secretase at lower IC50 values than donepezil; in vitro assays warrant further preclinical validation.