Role of sirtuin 6 in early vascular aging in young and middle-aged patients with coronary artery disease (literature review)

Coronary artery disease (CAD) remains the leading cause of disability and high mortality, including among working-age people. One of the most common causes of CAD in young people is early vascular aging (EVA). Studying the regulatory role of sirtuin 6 in the development of EVA seems relevant. The purpose of the review was to analyze the literature data on the possible influence of sirtuin 6 on EVA in young and middle-aged patients with CAD. For this purpose, we searched data in international (PubMed, Scopus, Web of Science and Cochrane Library) and Russian (eLIBRARY and CyberLeninka) databases. Particular attention was paid to works published over the past 15 years, with an emphasis on studies conducted over the past 5 years. Literature analysis showed that sirtuin 6, epigenetically modulating gene transcription and changing protein function, is involved in the main mechanisms of aging and related cardiovascular diseases. Thus, studying the effects of sirtuin 6 will provide a more detailed understanding of complex interaction, systemic factors and the development of cardiovascular pathology.