A simple, accurate UV-Spectrophotometric method has been developed using a dissolution media, 0.1% Tween 20 as a solvent to determine the methylprednisolone. At a predetermined λmax of 245 nm, method was proved linear in the range of 5-40 μg/ml with good correlation coefficient (R2=0.998) and excellent recovery (between 98 and 101%). This method was successfully applied to the determination of methylprednisolone from dissolution media, 0.1% Tween 20 aqueous solution. This method can be employed for the dissolution study of methylprednisolone in injectable suspension.
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Mhetre et al. (2024) studied this question.
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