Animal study reveals IL-37 ameliorates myocardial fibrosis in diabetic cardiomyopathy mice, highlighting a therapeutic mechanism against heart failure.
Diabetic cardiomyopathy (DCM), a serious complication of diabetes, leads to structural and functional abnormalities of the heart and ultimately evolves to heart failure. IL-37 exerts a substantial influence on the regulation of inflammation and metabolism. Whether IL-37 is involved in DCM is unknown.
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Huang et al. (2024) studied this question.
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