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May 24, 2024Journal of AutoimmunityOpen Access

Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjögren's syndrome: Novel biomarkers for disease activity and subsets

Jacob Ritter Franziska Szelinski Arman Aue Ana‐Luisa Stefanski Héctor Rincón-Arévalo Yidan Chen Eduard Nitschke Van Duc Dang Annika Wiedemann Eva Schrezenmeier Andreia C. Lino Thomas Dörner

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Abstract

Autoreactive B cells and interferon (IFN) signature are hallmarks of primary sjögren's syndrome (pSS), but how IFN signaling pathways influence autoantibody production and clinical manifestations remain unclear. More detailed studies hold promise for improved diagnostic methodologies and personalized treatment.

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Ritter et al. (2024) studied this question.

synapsesocial.com/papers/68e6885db6db64358761081b https://doi.org/10.1016/j.jaut.2024.103243

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