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May 23, 2024ACS Medicinal Chemistry Letters

Design Principle of Heparanase Inhibitors: A Combined In Vitro and In Silico Study

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Authors

YZYuzhao ZhangMXMeijun XiongZCZixin Chen

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Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e68ab9b6db643587612d05https://doi.org/10.1021/acsmedchemlett.3c00268
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy2016 · 227 citations
  2. 2Heparanase: A Challenging Cancer Drug Target2019 · 77 citations
  3. 3Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo2022 · 49 citations
  4. 4Upregulated Expression of Heparanase and Heparanase 2 in the Brains of Alzheimer’s Disease2017 · 55 citations
  5. 5Characterization of binding profiles of heparanase with existing small-molecule inhibitors using computational methods2023 · 2 citations