Clinical Effect Analysis of Metadoxine in the Treatment of Acute Severe Alcoholism

Objective: To observe the clinical effect of metadoxine in the treatment of acute severe alcoholism.Methods: A total of 86 patients with acute severe alcoholism admitted to our hospital from January 2022 to January 2023 were randomly selected for study, and divided into an observation group (treated with naloxone hydrochloride + metadoxine) and a control group (treated with naloxone hydrochloride) according to random number table method, and the clinical effects of the two groups were compared.Results: At admission, there was no significant difference in blood alcohol concentration between the two groups (P>0.05).In the follow-up tests 1h, 2h, and 4h after admission, the blood ethanol concentration of the observation group was significantly lower than that of the control group, with no statistical significance (P<0.05).The waking time, discharge time, and incidence of adverse reactions in the observation group were significantly lower than those in the control group, with no statistical significance (P<0.05).Conclusion: The treatment of metadoxine in patients with acute severe alcoholism can significantly improve the concentration of alcohol in the body and reduce the discharge time of patients, which has clinical popularization value.