Transition‐Metal‐Catalyzed Reactions Involving Trifluoro Diazo Compounds and Their Surrogates

Fluorinated organic compounds represent an important and growing family of active ingredients in various fields, including material science, pharmaceutical chemistry and biological science. Developing efficient synthetic methods toward fluorinated organic compounds have attracted much attention. In recent years, transition‐metal catalyzed reaction of trifluoro diazo compounds were a powerful and convenient approach to afford trifluoromethyl‐ and difluoromethyl‐substituted compounds of value. In this review, the recent progress on transition‐metal‐catalyzed reactions involving trifluoro diazo compounds and their surrogates via trifluoromethylated transition‐metal carbene complex is described in the sequence of 2,2,2‐trifluorodiazoethane as carbene precursor, ethyl 3‐trifluoro‐2‐diazo‐propionate as carbene precursor, trifluoroethylamine hydrochloride or amines as the CF 3 CHN 2 surrogate as well as trifluoro aldehydes/ketones N‐sulfonylhydrazones as the trifluoro diazo compounds surrogate.