Cell of origin epigenetic priming determines susceptibility to Tet2 mutation

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Single-cell multiomic profiling of gene mutation, chromatin accessibility, and gene expression in TET2-mutant clonal hematopoiesis2025
2. 2Human TET2-mutant clonal hematopoiesis expansion is driven by distinct inflammatory signaling responses in stem cells versus myeloid progeny.2025 · 8 citations
3. 3Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging2024 · 123 citations
4. 4Bone marrow environmental alterations underlie proliferative clonal expansion in clonal hematopoiesis2025
5. 5Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation2024 · 17 citations