Experimental analysis reveals thermal-induced beat-to-beat alternans in live explanted hearts, highlighting nonlinear voltage-calcium dynamics in cardiac arrhythmia.
Temperature plays a crucial role in influencing the spatiotemporal dynamics of the heart. Electrical instabilities due to specific thermal conditions typically lead to early period-doubling bifurcations and beat-to-beat alternans. These pro-arrhythmic phenomena manifest in voltage and calcium traces, resulting in compromised contractile behaviors. In such intricate scenario, dual optical mapping technique was used to uncover unexplored multi-scale and nonlinear couplings, essential for early detection and understanding of cardiac arrhythmia.
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Crispino et al. (2024) studied this question.
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