Key result
Temperature variations influence proarrhythmic dynamics, with complex discordant alternans patterns enhancing tissue dispersion observed in both simulations and canine right ventricle experiments.
Temperature variations significantly influence proarrhythmic dynamics such as restitution, conduction velocity, and alternans in cardiac tissue models and canine right ventricles.
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Temperature effects on alternans warrant inclusion in proarrhythmia models; leaves open clinical translation.
Thermal effects affecting spatiotemporal behavior of cardiac tissue are discussed by relating temperature variations to proarrhythmic dynamics in the heart. By introducing a thermoelectric coupling in a minimal model of cardiac tissue, we are able to reproduce experimentally measured dynamics obtained simultaneously from epicardial and endocardial canine right ventricles at different temperatures. A quantitative description of emergent proarrhythmic properties of restitution, conduction velocity, and alternans regimes as a function of temperature is presented. Complex discordant alternans patterns that enhance tissue dispersion consisting of one wave front and three wave backs are described in both simulations and experiments. Possible implications for model generalization are finally discussed.
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Fenton et al. (2013) studied Proarrhythmic dynamics. Temperature variations vs. Different temperatures was evaluated on Proarrhythmic properties of restitution, conduction velocity, and alternans regimes. Temperature variations influence proarrhythmic dynamics, with complex discordant alternans patterns enhancing tissue dispersion observed in both simulations and canine right ventricle experiments.
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